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Carolina Panthers schedule: 2022 opponents

Andrew Buller-Russ
Carolina Panthers schedule and 2021 season predictions
Bob Donnan-USA TODAY Sports

Carolina Panthers schedule: Opponents for 2022 season

  • Home: Cardinals, Falcons, Browns, Broncos, Lions, Saints, Steelers, 49ers, Buccaneers
  • Away: Falcons, Ravens, Bengals, Rams, Saints, Giants, Seahawks, Buccaneers

Disclaimer: All our predictions are based on the Panthers keeping and starting these key players:

See where the Panthers fall in our latest NFL power rankings

Carolina Panthers 2021 season results

Week 1 – Carolina Panthers won 19-14 vs. New York Jets

  • When: Sunday, Sept. 12 at 1:00 PM on CBS
  • Spread: Panthers -4
  • Moneyline: Jets +190; Panthers -235
  • Over/under: 44.5
  • Sportsnaut Prediction: Jets 30, Panthers 20

Week 2 – Carolina Panthers won 26-7 vs. New Orleans Saints

  • When: Sunday, Sept. 19 @ 1:00 PM on FOX
  • Spread: Saints -3.0
  • Moneyline: Panthers +160; Saints -195
  • Over/Under: 44.5
  • Sportsnaut prediction: Panthers 31, Saints 27

Week 3 — Carolina Panthers won 24-9 @ Houston Texans

  • When: Thursday, September 23 at 8:20 PM EST on NFL Network
  • Spread: Panthers -8.0 (BetMGM)
  • Over/Under: 43 points
  • Money line: Panthers (-350), Texans (+275)
  • Sportsnaut prediction: Panthers 21, Texans 10

Week 4 – Panthers lose 36-28 to Dallas Cowboys

  • When: Sunday, Oct. 3 at 1:00 PM
  • Point spread: Cowboys -4.5
  • Moneyline: Panthers +170; Cowboys -210
  • Over/under: 51.0
  • Sportsnaut prediction: Cowboys 24, Panthers 20

Week 5 – Carolina Panthers lose 21-18 to Philadelphia Eagles

  • When: Sunday, Oct. 10 at 1:00 PM
  • Spread: Panthers -3
  • Moneyline: Eagles +150; Panthers -180
  • Over/Under: 45
  • Sportsnaut prediction: Panthers 27, Eagles 16

Week 6 – Carolina Panthers lose 34-28 vs. Minnesota Vikings

  • When: Sunday, Oct. 17 at 1:00 PM
  • Spread: Vikings -2
  • Moneyline: Minnesota -135; Carolina +115
  • Over/under: 46
  • Sportsnaut prediction: Vikings 24, Panthers 17

Week 7 – Panthers lose 25-3 to New York Giants

  • When: Sunday, Oct. 24 at 1:00 PM
  • Spread: Panthers -3
  • Moneyline: Carolina -150; New York Giants +125
  • Over/under: 43
  • Sportsnaut prediction: Panthers 27, Giants 17

Week 8 – Panthers win 19-13 vs Atlanta Falcons

  • When: Sunday, Oct. 31 at 1:00 PM
  • Spread: Falcons -3
  • Moneyline: Carolina +135; Atlanta -165
  • Over/under: 47
  • Sportsnaut prediction: Falcons 24, Panthers 13

Week 9 – Carolina Panthers lose 24-6 to New England Patriots

  • When: Sunday, Nov. 7 at 1:00 PM
  • Spread: Patriots -3.5
  • Moneyline: New England -185; Carolina +155
  • Over/under: 41.5
  • Sportsnaut prediction: Panthers 17, Patriots 13

Week 10 – Carolina Panthers win 34-10 over Arizona Cardinals

  • When: Sunday, Nov. 14 at 1:00 PM
  • Spread: Cardinals -10.0
  • Moneyline: Carolina +375; Arizona -500
  • Over/under: 44.5
  • Sportsnaut prediction: Cardinals 31, Panthers 17

Week 11 – Carolina Panthers lose 27-21 to Washington Football Team

  • When: Sunday, Nov. 21 at 1:00 PM
  • Spread: Carolina -2
  • Moneyline: Washington +110; Carolina -130
  • Over/under: 43
  • Sportsnaut prediction: Panthers 24, Washington 10

Week 12 – Panthers lose 33-10 to Miami Dolphins

  • When: Sunday, Nov. 28 at 1:00 PM
  • Spread: Carolina -2
  • Moneyline: Panthers -135; Dolphins +115
  • Over/under: 42
  • Sportsnaut prediction: Panthers 20, Dolphins 13

Week 13 BYE

Week 14 – Carolina Panthers lose 29-21 vs. Atlanta Falcons

  • When: Sunday, Dec. 12 at 1:00 PM
  • Spread: Panthers -3
  • Moneyline: Atlanta +120; Carolina -140
  • Over/under: 45
  • Sportsnaut prediction: Falcons 32, Panthers 24

Week 15 – Panthers lose 31-14 to Buffalo Bills

  • When: Sunday, Dec. 19 at 1:00 PM
  • Spread: Bills -10.5
  • Moneyline: Carolina +320; Buffalo -425
  • Over/under: 44.5
  • Sportsnaut prediction: Bills 38, Panthers 21

Week 16 – Carolina Panthers lose 32-6 to Tampa Bay Buccaneers

  • When: Sunday, Dec. 26 at 1:00 PM
  • Spread: Buccaneers -10
  • Moneyline: Tampa Bay -450; Carolina +340
  • Over/under: 42.5
  • Sportsnaut prediction: Buccaneers 42, Panthers 24

Week 17 – Carolina Panthers lose 18-10 to New Orleans Saints

  • When: Sunday, Jan. 2 at 4:25 PM
  • Spread: Saints -6.5
  • Moneyline: Carolina +230; New Orleans -280
  • Over/under: 37.5
  • Sportsnaut prediction: Panthers 21, Saints 13

Week 18 – Carolina Panthers lose 41-17 to Tampa Bay Buccaneers

  • When: Sunday, Jan. 9
  • Spread: Buccaneers -16.5
  • Moneyline: Carolina +950; Tampa Bay -1750
  • Over/under: 43
  • Sportsnaut prediction: Buccaneers 38, Panthers 17

Come back next season for the 2022 Carolina Panthers schedule.