Mahomes completed all but one of his nine pass attempts and achieved a perfect 158.3 passer rating. Backup quarterback Shane Buechele went 20 of 33 for 231 yards with two TDs and one interception for the Chiefs (3-0).
Kirk Cousins threw for 57 yards on 5-of-7 passing for the Vikings (0-3). A.J. Rose Jr., a rookie out of Kentucky, ran for two touchdowns and gained 41 yards on six carries.
Panthers 34, Steelers 9
Sam Darnold threw two first-half touchdown passes as Carolina routed Pittsburgh in Charlotte.
Darnold finished 19 of 25 for 162 yards, and Spencer Brown and Will Grier added rushing touchdowns for the Panthers (1-2).
Dwayne Haskins completed 9 of 16 passes for 108 yards with one touchdown and one interception for the Steelers (3-1).
Colts 27, Lions 17
Deon Jackson caught a game-tying, 3-yard touchdown pass in the fourth quarter and later added a 42-yard TD run as Indianapolis won at Detroit.
Jackson ran for 81 yards on 10 carries, and Jacob Eason completed 10 of 14 passes for 74 yards to lead the Colts (3-0).
David Blough went 13 of 21 for 117 yards and an interception for the Lions (0-3).
Jets 31, Eagles 31
Kenny Yeboah hauled in a 49-yard touchdown catch from James Morgan in the final seconds, and Josh Adams’ two-point conversion carry lifted New York to a tie with Philadelphia in East Rutherford, N.J.
Yeboah, who scored on a 21-yard catch from Morgan earlier in the fourth quarter, finished with 100 yards receiving on four catches. Morgan had 158 yards passing with the two touchdowns and one interception, while Adams ran for 62 yards on 12 carries for the Jets (2-0-1).
Joe Flacco connected on 13 of 16 passes for 188 yards and two touchdowns for the Eagles (0-2-1).
–Field Level Media