Clemson Football Schedule and 2021 season predictions

Clemson football schedule this week

Week 5 – vs. Boston College Eagles

DateTime (ET)TV
Saturday, Oct. 27:30 p.m.ACCN

Clemson’s College Football Playoff hopes are over. It’s the earliest we’ve seen this happen to the Tigers in years and now a young team must prove it can rebound. Fortunately, the Boston College Eagles are on the schedule.

  • Week 5 prediction: Clemson 41, Boston College 24

Click here to keep up with every game on the schedule in our College Football Games Today flagship post

Clemson football schedule predictions, roster outlook

  • Clemson lost to the Georgia Bulldogs 10-3 in Week 1 of the college football season.
  • The Tigers’ bye is Week 6, and is set between ACC matchups vs. Boston College and at Syracuse (Oct. 2 and Oct. 15).
  • Sportsnaut predicts Clemson will end the regular season with an 11-1 record.

Let’s take a look at the team’s complete 2021 schedule and make predictions for each game.

Clemson football schedule predictions, roster outlook
Nov 28, 2020; Clemson, SC, USA; Clemson wide receiver Justyn Ross (8) warms up with his team before the game against Pittsburgh at Memorial Stadium. Mandatory Credit: Ken Ruinard-USA TODAY Sports

Clemson football roster outlook

All our predictions are based on the Tigers starting these key players:

  • QB – D.J. Uiagalelei
  • RB – Lyn-J Dixon, Kobe Pace, Chez Mellusi, Darien Rencher
  • WR – Justyn Ross, Joseph Ngata, E.J. Williams, Frank Ladson Jr.
  • TE – Braden Galloway, Davis Allen

Clemson lost their top three pass-catchers from 2020, including Etienne, and D.J. Uiagalelei is taking over under center for Lawrence. Uiagalelei showed out last season when pressed into action, which suggests he can be a worthy encore act to his legendary predecessor. With a deep backfield, two capable receiving tight ends, and Justyn Ross back from injury after missing 2020, look for the Tigers to lean on the run and play-action/RPOs more this year.

Week 1 – Clemson lost 10-3 vs. Georgia Bulldogs

  • When: Saturday, Sept. 4 at 7:30 PM on ABC
  • Spread: Clemson -3.5 (via DraftKings)
  • Moneyline: Georgia +125; Clemson -145
  • Sportsnaut Prediction: Clemson 28, Georgia 24

Kirby Smart is an excellent defensive mind and has a viable quarterback in JT Daniels. Despite losing cornerbacks Tyson Campbell and Eric Stokes to the NFL, Smart dialed up the heat on Clemson QB D.J. Uiagalelei, and forced him into a pick-six that proved costly, as Georgia defeated the Tigers 10-3 in Week 1.

Week 2 – Clemson won 49-3 vs. South Carolina State Bulldogs

  • When: Saturday, Sept. 11 at 5:00 PM on ACC Network
  • Sportsnaut Prediction: Clemson 49, South Carolina State 7

After the difficulty of Week 1, Clemson breathed a sigh of relief against an FCS opponent. It’s not like South Carolina State was going to be a total pushover, but there was no chance the massive underdogs would into Death Valley and pull off an upset. In an act of vengeance for their loss to kick off the season, the Tigers fired back with a big win.

Week 3 – Clemson won 14-8 vs. Georgia Tech Yellow Jackets

  • When: Saturday, Sept. 18 @ 3:30 PM on FS1
  • Spread: Clemson -28
  • Moneyline: Georgia Tech +2200; Clemson -6500
  • Over/under: 52
  • Sportsnaut prediction: Clemson 56, Georgia Tech 14

it’s truly stunning that Clemson failed to blow out the Yellow Jackets. D.J. Uiagalelei has gone from Heisman hopeful to barely-competent starting college quarterback. He threw for 125 yards on 25 attempts versus Georgia Tech. Maybe the season opener against Georgia shook his confidence. Whatever the case may be, you can see how heavily favored the Tigers were. They came out flat and almost suffered a huge upset.

Week 4 – Clemson lost to North Carolina State, 27-21

DateTime (ET)TV
Saturday, Sept. 253:30 PMESPN
  • Spread: Clemson -9.5 (via DraftKings)
  • Moneyline: North Carolina State +290; Clemson -380
  • Over/under: 47.5
  • Sportsnaut prediction: Clemson 35, NC State 10

The Clemson Tigers came into this game with 36 consecutive victories against unranked opponents. That incredible streak is a thing of the past and there are now real problems for Dabo Swinney. D.J. Uiagalelei completed just 12-of-26 passes for 111 yards and the Tigers simply got outplayed in this stunning upset.

Clemson football schedule predictions

Clemson football schedule predictions
Jan 13, 2020; New Orleans, Louisiana, USA; Clemson Tigers tight end Braden Galloway (88) runs after a reception against the LSU Tigers in the College Football Playoff national championship game at Mercedes-Benz Superdome. Mandatory Credit: Matthew Emmons-USA TODAY Sports


Week 7 – @ Syracuse Orange

DateTime (ET)TV
Friday, Oct. 157:00 PMESPN

A prime-time national TV game fresh off the bye week is a great way to ensure Clemson doesn’t overlook the Orange. There’s little danger of an upset here, but the Tigers must be on their guard. Syracuse may have won only one game in 2020, but its non-conference slate was brutal, and the Orange actually kept within striking distance of Clemson in the third quarter of a 47-21 loss.

  • Week 7 prediction: Clemson 49, Syracuse 17

Week 8 – @ Pittsburgh Panthers

DateTime (ET)TV
Saturday, Oct. 23TBDTBD
  • Spread: Clemson -18 (via DraftKings)
  • Moneyline: Clemson -1000; Pittsburgh +650

Fifth-year senior quarterback Kenny Pickett is returning for Pittsburgh, whose only two truly ugly losses from last season were against Notre Dame and Clemson. Pickett at least provides experience and leadership at a key position, which should keep things competitive. However, the Tigers’ skill position players will overwhelm the Panthers in the end.

  • Week 8 prediction: Clemson 38, Pittsburgh 21

See where D.J. Uiagalelei ranks in our list of top 10 college football quarterbacks

Week 9 – vs. Florida State Seminoles

DateTime (ET)TV
Saturday, Oct. 30TBDTBD

If the Seminoles were living up to their typical reputation as a powerhouse, the ACC would be a lot more interesting. As it stands, though, Florida State is still a program searching for an identity amid a rebuild. The foundation isn’t yet there to notch quality road wins against elite opponents.

Week 9 prediction: Clemson 48, Florida State 24

Week 10 – @ Louisville Cardinals

DateTime (ET)TV
Saturday, Nov. 6TBDTBD

Malik Cunningham is an intriguing dual-threat QB who might give the Cardinals a puncher’s chance at pulling off a shocker in Louisville. This is definitely among the most dangerous foes for the Tigers down the stretch, but following a few facile wins, you can bet the visitors will be up to the task for this one and show how sharp they are for the College Football Playoff selection committee.

  • Week 10 prediction: Clemson 41, Louisville 27

Week 11 – vs. UConn Huskies

DateTime (ET)TV
Saturday, Nov. 13TBDTBD

So, the Huskies are much better known as a basketball school, won only two games during the 2019 campaign, and didn’t have a season last year. This seems like a pretty sure bet that Clemson will cover the spread, no matter how high it is.

  • Week 11 prediction: Clemson 63, UConn 0
Clemson football schedule predictions
Oct 31, 2020; Clemson, South Carolina, USA; Clemson Tigers quarterback D.J. Uiagalelei (5) returns the ball to a referee after a 30-yard run for a touchdown against the Boston College Eagles during the third quarter at Memorial Stadium. Mandatory Credit: Josh Morgan-USA TODAY Sports

Week 12 – vs. Wake Forest Demon Deacons

DateTime (ET)TV
Saturday, Nov. 20TBDTBD

You can’t really say the Demon Deacons are a total cupcake matchup, because they really battled last year, losing by three to NC State, six to North Carolina and would’ve probably beat Wisconsin in a bowl game if not for four interceptions thrown by Sam Hartman. But Carlos Basham Jr. is no longer on Wake Forest’s defensive line, and its offense just isn’t good enough to keep up with the Tigers.

  • Week 12 prediction: Clemson 52, Wake Forest 14

Week 13 – @ South Carolina Gamecocks

DateTime (ET)TV
Saturday, Nov. 27TBDTBD

Wow, and to cap off the regular season, we have the Palmetto Bowl between Clemson and South Carolina. The big issue here is the coaching matchup. Shane Beamer is in his first year at the helm of the Gamecocks, and will have just endured a brutal SEC gauntlet, only to face one of the top-flight teams in the country to cap off his maiden season. Swinney and Clemson’s staff will have an edge too overwhelming for the hosts to overcome.

  • Week 13 prediction: Clemson 37, South Carolina 17

Clemson Tigers record prediction: 12-0