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San Francisco 49ers schedule: It all starts with the Bears in Chicago

Vincent Frank

San Francisco 49ers schedule: Week 1

DateOpponentTime (ET)TV
Sunday, Sep 11@ Chicago Bears1:00 PMFOX

San Francisco 49ers roster outlook

  • QB — Trey Lance, Jimmy Garoppolo
  • RB — Elijah Mitchell, JaMycal Hasty, Trey Sermon, Jeff Wilson, Tyrion Davis-Price
  • FB — Kyle Juszczyk
  • TE — George Kittle, Ross Dwelley, Charlie Woerner
  • WR — Deebo Samuel, Brandon Aiyuk, Jauan Jennings, Danny Gray, Ray-Ray McCloud, Marcus Johnson, Malik Turner

The San Francisco 49ers find themselves in an interesting situation with both Lance and Garoppolo still on the roster. San Francisco looked to trade Garoppolo earlier in the offseason, but a shoulder injury impacted the team big time.

Head coach Kyle Shanahan and Co. still have one of the most-talented rosters in the NFL. On offense, it’s going to be all about whether Lance can prove he’s the guy under center.

Defensively, there’s a lot to like about this unit. Nick Bosa, Fred Warner and Jimmie Ward headline the three levels with a nice mix of youngsters.

Find out where the San Francisco 49ers stand in our most-recent NFL power rankings

2022 San Francisco 49ers preseason opponents

  • Preseason Week 1: Green Bay Packers
  • Preseason Week 2: @ Minnesota Vikings
  • Preseason Week 3: @ Houston Texans

2022 San Francisco 49ers schedule

san francisco 49ers schedule
Stan Szeto-USA TODAY Sports

Here, you can find all of the information you need on the 2022 San Francisco 49ers. We’ll provide game predictions, betting info and more throughout the season.

Week 2 — Seattle Seahawks

DateGameTime (ET)TV Info
Sunday, Sep. 18Seahawks4:05 PMFOX
  • Prediction: 49ers 28, Seahawks 17

Week 3: @ Denver Broncos

DateGameTime (ET)TV Info
Sunday, Sep. 25@ Broncos8:20 PMNBC
  • Prediction: Broncos 31, 49ers 23

Week 4: Los Angeles Rams

DateGameTime (ET)TV Info
Monday, Oct. 3Rams8:15 PMESPN
  • Prediction: 49ers 28, Rams 23

Week 5: @ Carolina Panthers

DateGameTime (ET)TV Info
Sunday, Oct. 9@ Panthers4:05 PMCbS
  • Prediction: 49ers 31, Panthers 17

Week 6: @ Atlanta Falcons

DateGameTime (ET)TV Info
Sunday, Oct. 16@ Falcons1:00 PMFOX
  • Prediction: 49ers 35, Falcons 17

Week 7: Kansas City Chiefs

DateGameTime (ET)TV Info
Sunday, Oct. 23Chiefs4:25 PMFOX
  • Prediction: Chiefs 31, 49ers 21

Week 8: @ Los Angeles Rams

DateGameTime (ET)TV Info
Sunday, Oct. 30@ Rams4:25 PMFOX
  • Prediction: Rams 27, 49ers 20

Week 9: Bye

Week 10: Los Angeles Chargers

DateGameTime (ET)TV Info
Sunday, Nov. 13Los Angeles Chargers8:20 PMNBC
  • Prediction: Chargers 35, 49ers 24

Week 11: @ Arizona Cardinals (Mexico City)

DateGameTime (ET)TV Info
Monday, Nov. 21@ Cardinals8:15 PMESPN
  • Prediction: 49ers 27, Cardinals 17

Week 12: New Orleans Saints

DateGameTime (ET)TV Info
Sunday, Nov. 27Saints4:25 PMFOX
  • Prediction: 49ers 27, Saints 16

Week 13: Miami Dolphins

DateGameTime (ET)TV Info
Sunday, Dec. 4Dolphins4:05 PMFOX
  • Prediction: 49ers 24, Dolphins 20

Week 14: Tampa Bay Buccaneers

DateGameTime (ET)TV Info
Sunday, Dec. 11Buccaneers4:25 PMFOX
  • Prediction: Buccaneers 31, 49ers 24

Week 15: @ Seattle Seahawks

DateGameTime (ET)TV Info
Thursday, Dec. 15@ Seahawks8:15 PMPrime Video
  • Prediction: 49ers 27, Seahawks 17

Week 16: Washington Commanders

DateGameTime (ET)TV Info
Saturday, Dec. 24Commanders4:05 PMCBS
  • Prediction: 49ers 31, Commanders 16

Week 17: @ Las Vegas Raiders

DateGameTime (ET)TV INFO
Sunday, Jan. 1@ Raiders4:05 PMFOX
  • Prediction: Raiders 27, 49ers 24

Week 18: Arizona Cardinals

DateGameTime (ET)TV Info
  • Prediction: 49ers 27, Cardinals 20

San Francisco 49ers schedule prediction: 11-6, 2nd place in the NFC West

It’s really going to be all about the quarterback position in San Francisco. As we saw last season, this team can still make it far in the postseason with average QB play.

Still stingy on defense and boasting some elite skill-position players on offense, above-average quarterback play could make the difference. Whether there’s confidence in Lance providing that as a first-time full-time starter remains to be seen.

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