49ers quarterback Jimmy Garoppolo during training camp
Sep 2, 2020; Santa Clara, CA, USA; San Francisco 49ers quarterback Jimmy Garoppolo (10) walks to the field during training camp at Levi s Stadium. Mandatory Credit: San Francisco 49ers/Pool Photo via USA TODAY Network

The San Francisco 49ers head into their Week 3 outing against the New York Giants banged up pretty bad on the offensive side of the ball following a season-opening loss to the Arizona Cardinals and a blowout Week 2 win over the Jets. They are also without multiple components on defense. That includes reigning NFL Defensive Rookie of the Year Nick Bosa, who is out for the remainder of the season.

Meanwhile, quarterback Jimmy Garoppolo has been ruled out after suffering a high-ankle sprain during Week 2’s win over the New York Jets.

Below, we break down the 49ers’ injuries and what they mean for Week 3 against the Giants and beyond.

Related: NFL Week 3 power rankings

San Francisco 49ers schedule

Jimmy Garoppolo injury update

  • Position: Quarterback
  • Status: Out
  • Injury: High-ankle sprain
  • Team Impact: San Francisco had previously said that Garoppolo could very well go Week 3 against an iffy Giants defense. Given the turf concerns at the Meadowlands in Jersey, it makes sense that the 49ers ruled him out. Instead, backup Nick Mullens will get the start with Garoppolo likely returning Week 4 against the Eagles.
  • Fantasy Impact: The Giants have given up five touchdowns to two interceptions for a near 100 quarterback rating in two games. That included going up against Mitchell Trubisky in Week 2. If Mullens is under center, he’s a sneaky play in daily leagues. If, for some reason, Garoppolo is a go, expect a top-10 fantasy performance in Week 4.

Related: NFL Week 3 schedule, predictions

Nick Bosa injury update

  • Position: Defensive end
  • Status: Out (injured reserve)
  • Injury: Torn ACL
  • Team Impact: Obviously, this is a major blow for the 49ers. Missing out on their top defensive player for the remainder of the season is going to hurt big time. Bosa, 22, recorded 25 quarterback hits and nine sacks last season.
  • Fantasy Impact: The 49ers are also without Dee Ford (more on him later). Missing out on two Pro Bowl edge rushers is no small thing. The recently-signed Ezekiel Ansah will be active for Week 3, as will former Miami Dolphins top-five pick Dion Jordan. Even then, Daniel Jones is not a fantasy option here without Saquon Barkley (torn ACL) in the mix.

Related: How rash of injuries impacts NFL trade deadline

Deebo Samuel injury update

  • Position: Wide receiver
  • Status: Out (injured reserve)
  • Injury: Foot
  • Team Impact: Samuel will miss at one more game. The expectation is that he will be able to go Week 4 against the Philadelphia Eagles after suffering a Jones fracture in his foot during off-season workouts.
  • Fantasy Impact: After putting up north of 1,000 yards as a rookie, Samuel’s absence was felt big time in Week 1. Jimmy Garoppolo completed just 4-of-11 passes to his wide receivers. The hope is that Kendrick Bourne can improve off a substandard opener. Fellow Week 1 starter Dante Pettis is irrelevant after failing to catch a pass last week. However, Brandon Aiyuk made his debut last week and could be a stash option.

Related: NFL Week 3 odds

Raheem Mostert injury update

  • Position: Running back
  • Status: Out
  • Injury: Knee
  • Team Impact: One of the most-explosive backs in the NFL, Mostert opened last week’s scoring with an 80-yard touchdown run. That came after he caught a long touchdown in Week 1. All said, the former undrafted free agent is averaging a whopping 6.7 yards per touch since the start of last season.
  • Fantasy Impact: With Mostert (and Tevin Coleman) out in this one, San Francisco will be forced to rely on Jerick McKinnon. He’s a solid daily play against a suspect Giants defense. After missing each of his first two seasons with the 49ers (torn ACL), McKinnon has performed well in limited action this year. He’s averaging an eye-opening 13.4 yards per touch through two games.

George Kittle injury update

  • Position: Tight end
  • Status: Out
  • Injury: Knee
  • Team Impact: The game’s best tight end is obviously a major component to San Francisco’s success on offense. Kittle caught four passes before going down to injury in Week 1. He didn’t record a single reception once returning to the game. That tells us something.
  • Fantasy Impact: Kittle is now officially out for Week 3 against the Giants. As with Garoppolo, it was hard to envision San Francisco risking further injury due to the questionable field in Jersey. With Kittle out, Jordan Reed becomes an option. He scored two touchdowns last week.

Related: NFL Week 3 locks

Tevin Coleman injury update

  • Position: Running back
  • Status: Out
  • Injury: Knee
  • Team Impact: Coleman has touched the ball 21 times in two games, averaging a poor 3.0 yards per touch. That’s not going to get it done in Kyle Shanahan’s running back-friendly offense. This injury moves other more promising backs up a notch on the depth chart.
  • Fantasy Impact: Former undrafted free agents Jeff Wilson and JaMycal Hasty will likely be active in this one. A third-year player out of North Texas, Wilson scored five touchdowns on just 30 touches a season ago. As for Hasty, take a wait-and-see approach. Primarily, it will be interesting to see how much Shanahan relies on McKinnon in Week 4.

Richard Sherman injury update

  • Position: Starting cornerback
  • Status: Out (injured reserve)
  • Injury: Calf
  • Team impact: San Francisco’s decision not to add another starter-caliber corner during the offseason is now magnified. Emmanuel Moseley and Ahkello Witherspoon are not the answers. Relying on a player in Jason Verrett who has suited up in five games since the end of the 2015 season is also problematic.
  • Fantasy impact: This week’s game against the Giants likely won’t be impacted too much. Simply put, Daniel Jones does not have weapons to beat a top defense. Sherman will also miss Week 4’s game. That could make Carson Wentz a viable option for the Eagles.

Dee Ford injury update

  • Position: Defensive end
  • Status: Out
  • Injury: Back, neck
  • Team Impact: A blockbuster acquisition of the 49ers ahead of the 2019 season, Ford suffered through an injury-plagued first campaign with the team. He recorded 6.5 sacks in 11 games. With that said, San Francisco’s defense was a complete monster with both Ford and Bosa on the field.
  • Fantasy Impact: As noted before, being without both Bosa and Ford is going to loom large. San Francisco will now need to rely on Arik Armstead and rookie first-round pick Javon Kinlaw. This could be something to watch following Week 4’s outing against a bad Giants offense.