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NFL Week 1: 5 teams on upset alert, including the San Francisco 49ers

NFL Week 1, San Francisco 49ers
Credit: Stephen R. Sylvanie-Imagn Images

The full slate of NFL Week 1 games kick off this Sunday and the anticipation is off the charts. Any given week, there are always certain teams who are favored and end up getting upset on game day. In Week 1, especially, it’s hard to predict how games will go. One costly turnover or a big breakout game from a player can determine a game.

Some notable matchups this weekend includes a rematch of the NFC Wild Card Game with the Los Angeles Rams taking on the Detroit Lions. Additionally, there is an AFC South showdown as two young star quarterbacks in that of C.J. Stroud of the Houston Texans and Anthony Richardson of the Indianapolis Colts face off. Finally, on Monday night the New York Jets face off against the San Francisco 49ers. With that in mind, we give five teams who are on upset alert this weekend.

Related: NFL Week 1 expert picks

Detroit Lions against the Los Angeles Rams

Los Angeles Rams Matthew Stafford, Detroit Lions Jared Goff
Credit: David Reginek-Imagn Images

Why the NFL Week 1 upset?

Los Angeles Rams, Puka Nacua, Detroit Lions
Credit: David Reginek-Imagn Images

Indianapolis Colts against the Houston Texans

Indianapolis Colts, Houston Texans
Credit: Robert Scheer/IndyStar / USA TODAY NETWORK

Why the NFL Week 1 upset?

C.J. Stroud
Credit: Robert Scheer-Imagn Images

San Fransisco 49ers against the New York Jets

NFL: San Francisco 49ers at New York Jets
Credit: Vincent Carchietta-Imagn Images

Why the NFL Week 1 upset?

New York Jets training camp, Aaron Rodgers
Credit: John Jones-USA TODAY Sports

Atlanta Falcons against the Pittsburgh Steelers

Atlanta Falcons QB Kirk Cousins
Credit: Sam Navarro-USA TODAY Sports

Why the NFL Week 1 upset?

NFL Week 1, Pittsburgh Steelers, T.J. Watt
Credit: Charles LeClaire-Imagn Images

Cleveland Browns against the Dallas Cowboys

NFL: Cleveland Browns Training Camp
Credit: Bob Donnan-Imagn Images

Why the NFL Week 1 upset?

NFL Week 1: Micah Parsons
Credit: Joe Rondone / The Republic / USA TODAY NETWORK / USA TODAY NETWORK
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