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College Football Picks Week 10: LSU vs Alabama, Missouri vs Georgia and top 25 predictions

While there are college football games today, we won’t get to see any of the top-25 teams until Saturday. Fortunately, it won’t. be a long wait and there are college football picks for Week 10 to help look ahead to Saturday.

November is the most important time on the college football schedule. This is the moment of the season where the Heisman Trophy race will likely be decided and the committee will determine which teams make the College Football Playoff.

Related: 2023 college football rankings

With all of that in mind, let’s jump into our Week 10 college football picks for top 25 teams.

Week 10 college football picks: Predictions for top 25 games

NCAA Football: Brigham Young at Texas
Scott Wachter-USA TODAY Sports

The Week 10 lines and point totals are courtesy of BetMGM.

Ohio State vs Rutgers – 12:00 PM ET – CBS

  • Spread: Ohio State -18.5
  • Total: 42.5

While the Ohio State Buckeyes didn’t play their cleanest game in the victory over Wisconsin, it still marked their fourth consecutive win by eight points or more. This offense did suffer a blow with Miyan Williams lost for the year, but it’s balanced out with TreVeyon Henderson’s return to the lineup. For as impressive as Rutgers has been this season outside of matchups against top-30 teams, they now face the best program in the Nation. Ohio State should win this very comfortably.

  • Prediction: Ohio State 31, Rutgers 14

Related: Ohio State Buckeyes expected to lose multiple stars to 2024 NFL Draft

Kansas State vs Texas – 12:00 PM ET – FOX

  • Spread: Texas -4
  • Total: 49.5

Maalik Murphy has performed fairly well as the fill-in quarterback for the Texas Longhorns, but the Kansas State Wildcats are going to be a massive challenge. The Wildcats have allowed just under 330 total yards per game in the last three weeks, with the defense playing a huge role in the 41-point shutout win over Houston. This matchup feels like it will come down to the final possession and we’re putting Texas on upset watch.

  • Prediction: Kansas State 24, Texas 20

Related: Texas Football schedule

Texas A&M vs Ole Miss – 12:00 PM ET – ESPN

  • Spread: Ole Miss -3
  • Total: 54

We’ve learned not to trust Jimbo Fisher’s team in big games at Texas A&M, especially when you consider what happens to quarterback Max Johnson on the road. The Aggies’ quarterback has a 153.2 QB rating and 62.8% completion rate at home, with a 90.4 QB rating and 47.1% completion rate on the road. While Ole Miss might not be one of the most reliable teams in the nation, home-field advantage and a great run game swing it.

  • Prediction: Ole Miss 28, Teas A&M 21

Notre Dame vs Clemson – 12:00 PM ET – ABC

  • Spread: Notre Dame -3
  • Total: 44.5

In most years, a matchup between the Notre Dame Fighting Irish vs Clemson Tigers would be a toss-up in college football picks. This time around, it doesn’t feel particularly close. Even with Notre Dame missing tight end Mitchell Evans (ACL), the Fighting Irish have been a far superior team this season compared to Clemson. Even if the Tigers are more motivated after recent criticisms of their head coach, the eye tests says Notre Dame is the better football team.

  • Prediction: Notre Dame 20, Clemson 17

Related: Heisman Watch

UConn vs Tennessee – 12:00 PM ET – SEC Network

  • Spread: Tennessee -35.5
  • Total: 55.5

Not much to say here. The Tennessee Volunteers responded to their ugly second-half showing in Alabama with an impressive victory on the road in Kentucky. UConn has been one of the worst teams in college football this season, making this the perfect game for Joe Milton and Jaylen Wright to have monster Week 10 performances.

  • Prediction: Tennessee 41, UConn 7

Arizona State vs Utah – 2:00 PM ET – Pac-12 Network

  • Spread: Utah -11.5
  • Total: 40.5

The Arizona State Sun Devils have displayed a surprising amount of fight as of late, losing by one stored to Colorado and Washington then defeating Washington State. It certainly suggests the Sun Devils are headed in a positive direction, but a trip to Utah will likely end that. The Utes’ playoff chances were wiped out a week ago, but Week 10 offers Kyle Whittingham’s program a chance to rebound.

  • Prediction: Utah 23, Arizona State 13

Related: NFL Rookie of the Year candidates

Army vs Air Force – 2:30 PM ET – CBS Sports Network

  • Spread: Air Force -17.5
  • Total: 31.5

The Air Force Falcons have proven their perfect season is legitimate and now they get to take on a bad Army team. Already off to an 8-0 start, Air Force will come away with the win on Saturday and be one victory shy of three consecutive seasons with double-digit wins. This is really shaping up to be a historic year for the Falcons.

  • Prediction: Air Force 24, Army 7

Related: NFL coverage map Week 9

Missouri vs Georgia – 3:30 PM ET – CBS

  • Spread: Georgia -15.5
  • Total: 56.5

While the Georgia Bulldogs have demonstrated a habit of playing with their food in recent years, the most talented team in college football always delivers against marquee opponents. Missouri has been very impressive this year, but a trip to Georgia against a team that was ranked second in the CFP is a recipe for the Tigers’ disaster in Week 10.

  • Prediction: Georgia 34, Missouri 17

Related: Best college football teams of all time

Florida State vs Pittsburgh – 3:30 PM ET – ESPN

  • Spread: Florida State -21.5
  • Total: 50.5

The Florida State Seminoles might be one of the most well-rounded teams in the nation this fall. Not only can Jordan Travis add to his Heisman Trophy resume on Saturday with a fantastic performance against Pittsburgh, but the Seminoles’ defense can also wipe out just about everything the Panthers’ offense attempts.

  • Prediction: Florida State 31, Pittsburgh 10

Related: College Football Playoff picture

Oklahoma vs Oklahoma State – 3:30 PM ET – ABC

  • Spread: Oklahoma -6
  • Total: 61.5

It’s the final meeting in the classic Bedla Series rivalry before the Oklahoma Sooners head to the SEC. Oklahoma already started up the trash talk and its diminishing playoff hopes are clinging to the outcome of Week 10. However, this feels like one last shot for the Cowboys to ruin their rival’s season and Oklahoma State has played like the better team in recent weeks.

  • Prediction: Oklahoma State 31, Oklahoma 28

Related: College Football QB rankings

Penn State vs Maryland – 3:30 PM ET – FOX

  • Spread: Penn State -8.5
  • Total: 50.5

If the Maryland Terrapins were playing better football in October, we’d feel more comfortable putting Penn State on upset watch on the road in Week 10. However, the Terrapins have cooled off after looking promising and that leaves the door open for a motivated Penn State team to come out with a much-needed road win.

  • Prediction: Penn State 27, Maryland 17

Virginia Tech vs Louisville – 3:30 PM ET – ACC Network

  • Spread: Louisville -9.5
  • Total: 48.5

The loss to Pittsburgh becomes more perplexing with each passing week, but the Louisville Cardinals’ resume outside of that is actually one of the best in the nation. In this ACC clash, Louisville should prove why it’s got a chance to crack the top-10 rankings by late November.

  • Prediction: Louisville 28, Virginia Tech 17

Tulane vs East Carolina – 3:30 PM ET – ESPNU

  • Spread: Tulane -17
  • Total: 45.5

The Tulane Green Wave experienced a bit of a scare last week against Rice and their road trip isn’t over yet. However, Michael Pratt is far too good of a quarterback to let winnable games slip away and a 1-7 East Carolina team should pose no real trouble for the Green Wave.

  • Prediction: Tulane 31, East Carolina 10

California vs Oregon

  • Spread: Oregon -24.5
  • Total: 59.5

Bo Nix and Co. have rediscovered their rhythm as of late, rebounding from the loss to the Washington Huskies. In Week 10, a very winnable game against Cal should provide Nix with a shot to exploit the Bears’ defense, putting up the kind of stats that get him back in the conversation for the Heisman.

  • Prediction: Oregon 38, Washington 17

Related: 2024 NFL Draft order: Picks by team, Draft order

Kansas vs Iowa State

  • Spread: Iowa State -2.5
  • Total: 53.5

It’s another coin-flip matchup in Week 10, with both Iowa State and Kansas coming into Saturday night’s matchup with momentum on their side. The Cyclones have home-field advantage in their favor, but our feeling is the confidence boost from last weekend’s upset win will carryover against Iowa State.

  • Prediction: Kansas 27, Iowa State 24

Related: 2024 NFL mock draft

Purdue vs Michigan

  • Spread: Michigan -32.5
  • Total: 52.5

As long as the Michigan Wolverines keep facing unranked opponents, they’ll keep making the victories look like a cakewalk. There’s an us against the world mentality coming out of Ann Arbor right now and it should be more than enough in combination with the talent advantage to help the Wolverines wipe out Purdue.

  • Prediction: Michigan 38, Purdue 6

Related: Big 10 schools call on punishment for Michigan

Washington vs USC

  • Spread: Washington -3
  • Total: 76.5

If you’re looking for the highest-scoring game in Week 10, this is likely it. Caleb Williams and Michael Penix Jr will both put up eye-popping statistics on Saturday night, with the edge in this game given to the slightly better defense. Washington holds that edge by a significant margin, leading to another Huskies’ victory over a ranked opponent.

  • Prediction: Washington 45, USC 38

Related: USC Vs Washington Expert Predictions

LSU vs Alabama

  • Spread: Alabama -3
  • Total: 61.5

It comes down to LSU’s pass rush against Alabama’s offensive line and the Crimson Tide’s secondary lined up against the Tigers’ wide receivers. When comparing those matchups and the quarterbacks, the edge goes to LSU. What makes this come down to the final drive is Alabama’s home-field advantage and the Crimson Tide’s coaching edge.

  • Prediction: LSU 34, Alabama 31

Oregon State vs Colorado

  • Spread: Oregon State -13.5
  • Total: 62.5

If you make this a seven-on-seven matchup, we’ll take the Colorado Buffaloes at home. Unfortunately for Deion Sanders, his team does not have the talent or depth to even make this a close head-to-head matchup in the trenches. That’s why the Buffaloes are headed for another painful loss.

  • Prediction: Oregon State 38, Colorado 27

Related: NFL unlikely to save Jim Harbaugh

UCLA vs Arizona

  • Spread: UCLA -2.5
  • Total: 50.5

The UCLA Bruins are. atop-20 team, but they’ve lost twice this season and came narrowly close to defgeats in a few other matchups. On the other side, the Arizona Wildcats are feeling great after nearly defeating Washington. and USC, then finally getting the job done against Washington State and Oregon State. Give us the team that has looked better in the last three weeks.

  • Prediction: Arizona 27, UCLA 24
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