Several teams are on upset alert as we head into Week 6 of the NFL season. Beginning Thursday night, we have an NFC West showdown between the San Francisco 49ers against the Seattle Seahawks. Another notable game to watch this week is rookie sensation Jayden Daniels leading the Washington Commanders against Lamar Jackson and the Baltimore Ravens.
Which teams will most likely be upset in Week 6? Check out our list.
Seattle Seahawks over San Francisco 49ers
The 49ers are coming off an extremely disappointing loss at home against the Arizona Cardinals, 24-23. The Seahawks also lost at home last week against the New York Giants, 29-20. San Francisco is a 3.5-point favorite against the Seahawks on Thursday. We have the 49ers on upset alert.
Why the Week 6 upset?
The 49ers have not fared well against the Seahawks over the last decade. Since 2014, Seattle has won 14 of the last 20 regular season games between the two teams. Despite winning the last four regular season meetings, the 49ers have not been playing well in 2024. A trip to Seattle will not solve their woes.
Related: How To Watch Jets vs. 49ers: Time, Date, and How To Watch This Week
Washington Commanders over Baltimore Ravens
Both the Ravens and Commanders won last week. Washington defeated the Cleveland Browns in dominant fashion, 34-13. Baltimore was victorious in an overtime thriller against the Cincinnati Bengals, 41-38. This week, the Ravens are 6.5-point favorites against the Commanders. We have Baltimore on upset alert.
Why the Week 6 upset?
The Ravens rank last in pass defense, giving up 304 yards a game. Commanders rookie quarterback Jayden Daniels hasn’t had a 300-yard game yet in his career, but this week could be the opportunity for one as he has quickly ascended into one of the league’s best quarterbacks.
New York Giants over Cincinnati Bengals
The Bengals lost against the Baltimore Ravens in overtime last week, 41-38. The Giants beat the Seahawks in Seattle, 29-20. This week, the Bengals are 3.5-point favorites against New York. We have the Bengals on upset alert.
Why the Week 6 upset?
The Bengals’ defense ranks 31st in points allowed — second-to-last in the league — giving up 29 points a game. Additionally, they rank 30th in the NFL in rushing yards allowed. Look for the Giants to try to exploit the Bengals’ run defense and get on track.
Arizona Cardinals over Green Bay Packers
The Arizona Cardinals and Green Bay Packers are both coming off wins last week. Arizona pulled off a stunner on the road against the San Francisco 49ers, 24-23. The Packers are coming off a gritty road win against the Los Angeles Rams, 24-19. This week, Green Bay is a five-point favorite against the Cardinals.
Why the Week 6 upset?
The Packers’ defense is prone to giving up big plays in the passing game. Although Green Bay leads the league in takeaways through five weeks with 14, they also rank 25th in passing yards allowed per game, giving up 255 yards.
Tennessee Titans over Indianapolis Colts
The Titans were off last week as the Colts are coming off a heartbreaking loss to the Jacksonville Jaguars, 37-34. This week, Indianapolis is favored by a point against the Titans. We have the Colts on upset alert.
Why the Week 6 upset?
The Titans have the No. 1 pass defense in the league. Colts backup quarterback Joe Flacco lit up the Jaguars a week ago for 359 yards and three touchdowns in the loss. This week will be a big challenge as Tennessee only gives up 142 passing yards a game. Additionally, the Colts defense, as a whole, can’t stop a nosebleed, let alone the opposing offense as they give up 419 yards a game.