NFL Week 10 predictions: Projecting every game for Week 10, including Eagles vs Cowboys

This should be one of the best Thursday Night Football games in a few years. Even with Tee Higgins (quad) unlikely to go in Week 10, we’ve seen what Ja’Marr Chase (193 yards and 2 touchdowns) can do to this Baltimore Ravens secondary. With that said, the Cincinnati Bengals’ defense is even worse and has no answer for Lamar Jackson, Derrick Henry, Zay Flowers and Mark Andrews. In one of the highest-scoring games this week, Jackson delivers another MVP-caliber performance.

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It seems cruel to put Germany through this, but that was the NFL’s call. The New York Giants defensive line should wreak havoc in the Carolina Panthers backfield, already giving the G-Men a big edge in this matchup. Pair that with Malik Nabers and Tyrone Tracy Jr. facing the worst defense in football, New York should win this one comfortably.

The Chicago Bears desperately needed this one. Chicago’s game plan in Week 10 should be pretty simple, feed D’Andre Swift early against a bottom-10 run defense and then let Caleb Williams go to work against this secondary. Will that happen? It’s hard to say, Bears offensive coordinator Shane Waldron hasn’t exactly been drawing up smart game plans this year. Even with the Bears coaching staff weighing this team down, Chicago has enough talent on both sides of the ball to beat New England in Week 10.

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Josh Allen isn’t going to make as many mistakes as Sam Darnold did against this Indianapolis Colts defense. That means more opportunities for Khalil Shakir, Keon Coleman and Amari Cooper to attack a very vulnerable Colts secondary. Indianapolis could have some success on the ground with Jonathan Taylor, but the Buffalo Bills pass rush will force at least one Joe Flacco turnover and that should help lay the groundwork for a two-score win on Sunday.

Don’t sleep on the Denver Broncos potentially pulling off the upset in this one. The last time the Kansas City Chiefs faced a top-five defense, they narrowly escaped with a 17-10 win against the Los Angeles Chargers. We’re expecting a tight one here, but the Chiefs’ ability to successfully move the football on the ground and the fact that Steve Spagnuolo gets to cause chaos for rookie QB Bo Nix, should help Kansas City escape with a win over the Denver Broncos.

The New Orleans Saints’ season is over and there is blood in the water. While there’s a chance this veteran Saints roster rallies one last time against a division rival, we’ve seen far too much quit out of New Orleans this season. On the other side, the Atlanta Falcons have a chance to drive a nail into the Saints’ coffin. Quite frankly, if Atlanta can come out of this with a two-score win, that might be enough for the Saints to part ways with Dennis Allen.

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Both Christian McCaffrey and Jauan Jennings are returning in Week 10, providing a massive boost for this San Francisco 49ers offense. Kyle Shanahan should have great success scheming up explosive runs against a Tampa Bay Buccaneers defense that has allowed 5.2 yards per carry this season. Plus, with Mike Evans and Chris Godwin still out, the 49ers defense shouldn’t have much trouble ensuring Tampa Bay can’t keep pace with San Francisco’s offense.

This is one of our favorite matchups in Week 10. The Pittsburgh Steelers pass rush has been phenomenal this season and with the improvements made offensively, Arthur Smith and Mike Tomlin can control the clock more effectively to limit Jayden Daniels’ opportunities. With that said, Daniels is playing at an MVP-caliber level right now and we’ve seen him come through both in the clutch and against great pass rushes. We’re predicting another game-winning drive in the fourth quarter, securing a win that proves Washington is one of the best teams in the NFL.

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This could be a phenomenal Sunday for the Minnesota Vikings offense. Justin Jefferson is going to have a field day against this Jacksonville Jaguars secondary and if they put too much attention on him, Sam Darnold can find his way to 250-plus yards and 2 touchdowns with T.J. Hockenson and Jordan Addison. We do expect Trevor Lawrence to hit a few deep shots against the Vikings secondary, but Minnesota should control this one from start to finish.

It’s a Week 10 matchup between two of the best defenses in the NFL. That obviously sets the stage for a low-scoring game, but the Los Angeles Chargers hold massive advantages at quarterback and on special teams. While we do anticipate the Tennessee Titans at least making this game competitive, assuming they avoid multiple self-inflicted wounds (turnovers), the better roster and coaching staff come out with the victory.

Needless to say, this matchup loses some of its luster following injuries to Dak Prescott (hamstring), CeeDee Lamb (shoulder) and A.J. Brown (knee). We would have picked the Philadelphia Eagles to win even if the Dallas Cowboys offense was completely healthy, in large part because this isn’t an offense you really have to worry about when making a game plan. With Prescott and Lamb both uncertain for Week 10, Philadelphia should dominate and impose its will against its rival.

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This game is probably flying under the radar a bit, but it could be one of the more competitive matchups on Sunday. The Arizona Cardinals have the pass-catchers (Trey McBride and Marvin Harrison Jr.) and a highly effective rushing attack to exploit vulnerabilities in this New York Jets defense. Likewise, though, the trio of Breece Hall, Garrett Wilson and Davante Adams shouldn’t have much trouble creating explosive plays. Ultimately, we’re picking the more experienced team to come through with the win, but this matchup truly feels like a coin flip.

The Houston Texans offensive line can’t be fixed in a week and that is going to make this Sunday Night Football matchup a heck of a lot easier for the Detroit Lions defensively. C.J. Stroud also isn’t playing his best football right now and Lions defensive coordinator Aaron Glenn won’t hesitate to blitz him. As for the other side of the ball, there’s not a single defense in the NFL we think can contain the Lions offense for three quarters, let alone four.

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Just a few weeks ago, Matthew Stafford and Cooper Kupp were prominently floating around in NFL trade rumors. It’s because all hope seemed lost with the Los Angeles Rams coming out of the bye with a 1-4 record. A three-game winning streak changed everything. Los Angeles has proven itself against quality opponents (Minnesota Vikings, Seattle Seahawks and the Green Bay Packers). While the Miami Dolphins aren’t nearly as bad as their record would indicate, thanks to Tua Tagovailoa’s return, the Rams’ offensive firepower will pave the way to a fourth consecutive win.