NFL Week 11 offers us a ton of pretty huge matchups ahead of the holiday slate. It’s a time that things get real around the gridiron world.

This will start Thursday night with the Arizona Cardinals and Seattle Seahawks battling it out in the hotly-contested NFC West. Who boasts the point spread in this one? Do odds favor the Seahawks winning at home?

From there, both the Tennessee Titans and Baltimore Ravens will look to get back on track in a game between two struggling AFC contenders.

We look at this in our NFL Week 11 odds and point spreads with a bit of information for each game.

Update: Nov. 22, 9:55 AM EST

Related: NFL Week 11 schedule, predictions

NFL Week 11 Sunday games

NFL news: League expecting COVID-19 outbreak after Week 12?

Pittsburgh Steelers at Jacksonville Jaguars

Steelers-Jaguars Week 11 point spread: Steelers -10.5 (over/under 47.5)

Pittsburgh’s 9-0 start to the season has included the team registering a whopping 36 sacks. The Jaguars, in the midst of an eight-game losing streak, have now given up 28 sacks on the season. It’s no surprise that Ben Roethsliberger has put up 21 touchdowns and just four interceptions. He’s been sacked a grand total of 10 times in nine games. Meanwhile, the Jags have registered an awful nine sacks. Sometimes, it’s all about the trenches. Take Pittsburgh and the points here. Don’t think twice about it.

Related: NFL defense rankings: Saints rise, Patriots plummet entering Week 12.

Detroit Lions at Carolina Panthers

Lions-Panthers Week 11 point spread: Pick ‘Em (over/under 47.0)

Injury update: Teddy Bridgewater’s status

Injury update: Matthew Stafford active, D’Andre Swift and Kenny Golladay out

The Panthers’ defense has regressed each and every week during their five-game losing streak. Last Sunday’s 46-23 loss to the Tampa Bay Buccaneers added another layer to this. The Buccaneers gained 544 total yards of offense and a whopping 30 first downs. Surprisingly, the Lions are averaging north of 380 yards over the past five games. Expect these trends to continue with Detroit finally reaching .500 on the season.

New England Patriots at Houston Texans

Patriots-Texans Week 11 point spread: Patriots -2.0 (over/under 48.5)

The Patriots have now won two consecutive games after losing their previous four outings. Despite this, there’s still concern over the team’s defense. That two-game winning streak has included previously struggling quarterbacks Joe Flacco and Lamar Jackson go for north of 550 total yards with five touchdowns and two interceptions. For his part, Deshaun Watson is one of the few bright spots for the two-win Texans. He’s tallied 19 total touchdowns and five interceptions on the season. Take that into account when looking at Houston at +2.5 in this one.

Related: If you’re a fan of the Patriots, check out #GoPats rumors, rankings, and news here.

Tennessee Titans at Baltimore Ravens

Titans-Ravens Week 11 point spread: Titans-Ravens Week 11 point spread: Ravens -6.0 (over/under 50.0) -6.5 (over/under 49.0)

Update: Jadeveon Clowney placed on injured reserve

Struggles against struggles. That’s the best way to describe this matchup between two AFC title contenders. Tennessee’s decision to move on from defensive starters Vic Beasley and Johnathan Joseph has not necessarily panned out. Overall, the Titans are giving up an eye-opening 30.2 points per game in their past five outings. As for Lamar Jackson, the reigning NFL MVP has put up just five touchdown passes compared to three interceptions over the past three games. Baltimore at -6 seems iffy, at best.

Philadelphia Eagles at Cleveland Browns

Eagles-Browns Week 11 point spread: Browns -2.5 (over/under 45.5)

Update: Myles Garrett (COVID-19) out for Week 11

The last time Cleveland won its seventh game in a season before Thanksgiving was back in 1994. Interestingly enough, that game came against the Patriots with Bill Belichick serving as the Browns’ head coach (insert more you know GIF here). There’s a darn good chance that Baker Mayfield and Co. will repeat that feat Week 11 against the Eagles. Philadelphia’s three wins have come against teams with a combined 9-22 record. The team is 0-3 against squads with winning marks. Take Cleveland at -2.5 and don’t think twice about it.

Related: If you’re a fan of the Saints, check out #Saints rumors, rankings, and news here.

Atlanta Falcons at New Orleans Saints

Falcons-Saints Week 11 point spread: Saints -3.5 (over/under 9.0)

Injury update: Drew Brees (ribs, lung) out

It’s an interesting thing to look at. Despite his success as the Falcons’ starting quarterback dating all the way back to 2008, Matt Ryan has struggled big time against the Saints. He boasts a 9-24 record in 23 starts against his division rivals. He holds a .589 winning percentage against the NFL’s 31 other teams. As for the Saints, Jameis Winston will get the start for the injured Drew Brees. In reality, that might not be too much of a downgrade for New Orleans. Take the Saints, but leave the points in this NFL Week 11 game.

Cincinnati Bengals at Washington Football Team

Bengals-Washington Week 11 point spread: Washington -1.0 (over/under 47.0)

Washington is averaging 433 total yards and 26.5 first downs over the past two games, primarily with Alex Smith under center. This team had not put up 400 yards or more in 38 consecutive games prior Week 9. This tells us a story of an offense that has picked it up big time under Mr. Smith. It also leads us to believe that Washington will get its third win in 10 attempts this season against a Bengals defense that is yielding an average of 28 points per game on the season.

Related: Top NFL rookies of 2020

New York Jets at Los Angeles Chargers

Jets-Chargers Week 11 point spread: Chargers -10.0 (over/under 46.5)

This is something else. The Chargers are 2-7 on the season with all seven losses coming by one score. Dating back to the start of las season, Los Angeles is 3-16 in one-score games. As for the Jets, six of their nine losses this season have come by double digits. The moral of this story? If you’re going with the Chargers, take the points. If not, perhaps the Jets pull off their first win of the season.

Related: NFL playoff predictions

Miami Dolphins at Denver Broncos

Dolphins-Broncos Week 11 point spread: Dolphins -4.0 (over/under 46.0)

Injury update: Drew Lock (ribs) will start in Week 11

Some might look at the Dolphins’ 6-3 start to the season as a fluke. Given that four of those wins have come against teams who are currently under .500, this could make some sense. That’s until we realize that Miami ranks ninth in scoring offense and fifth in points against. The team has been darn good in all aspects of its game during this current five-game winning streak. As for Denver, its previously stout defense is giving up an average of 36 points over the past four games. Take Tua Tagovailoa and Co. with the points. Don’t think twice about it.

Dallas Cowboys at Minnesota Vikings

Cowboys-Vikings Week 11 point spread: Vikings -7.0 (over/under 49.5)

Injury update: Andy Dalton (concussions/COVID) to play

The Dallas Cowboys find themselves at 2-7 for the third time since the 2010 NFL season. For comparison’s sake, Dallas has won three playoff games over the past quarter century. That might seem random and meaningless here. But it’s obvious the prestige of America’s Team is no longer. Having lost four in a row while being outscored by a combined 98 points in nine outings this season, don’t expect Dallas to cover.

Related: If you’re a fan of the Cowboys, check out #DallasCowboys rumors, rankings, and news here.

Green Bay Packers at Indianapolis Colts

NFL Week 11: Philip Rivers and Colts against Packers
Philip Rivers (17) of the Indianapolis Colts takes a snap, Indianapolis Colts at Tennessee Titans, Nissan Stadium, Nashville, Thursday, Nov. 12, 2020. 22 Coltstitans Rs (© Robert Scheer/IndyStar via Imagn Content Services, LLC)

Packers-Colts Week 11 point spread: Colts -1.5 (over/under 51.5)

Strength against strength here. The Colts head into Week 11 fresh off a blowout win over the Tennessee Titans. They rank fourth in the NFL in points allowed at under 20 per game. Opposing quarterbacks have thrown 11 touchdowns compared to 11 interceptions against this unit. As for the Packers, Aaron Rodgers is leading the third-best scoring offense and has tossed 26 touchdowns against three picks. The one difference here? Green Bay has yielded a 101.1 opposing passer rating. Expect Philip Rivers to take advantage while helping Indy cover.

Week 11 Sunday Night Football

Kansas City Chiefs at Las Vegas Raiders

Chiefs-Raiders Week 11 point spread: Chiefs -7.5 (over/under 56.5)

Jon Gruden has had his team ready to play against top-end competition thus far this season. Las Vegas is 3-2 against winning teams, including victories over the Saints and these very same Chiefs through 10 weeks. The only blowout against a good team came during a Week 7 outing against Tampa Bay that saw the Bucs leading by one score in the fourth despite the Raiders dealing with a plethora of COVID-related issues. The math here suggests Kansas City will win, but won’t cover.

Related: Top 100 NFL players of 2020

NFL Week 11 Monday Night Football

Los Angeles Rams at Tampa Bay Buccaneers

NFL Week 11: Tom Brady and Buccaneers have big game
Nov 8, 2020; Tampa, Florida, USA;Tampa Bay Buccaneers quarterback Tom Brady (12) reacts as he threw an interception against the Tampa Bay Buccaneers during the first half at Raymond James Stadium. Mandatory Credit: Kim Klement-USA TODAY Sports

Rams-Buccaneers Week 11 point spread: Buccaneers -4.0 (over/under 48.5) 

Two teams that will more than likely be playing postseason football. Team teams battling for first place in their respective divisions. This is a statement game for both Jared Goff and his Rams and the Tom Brady-led Buccaneers. With that said, Tampa Bay at -4 does not make a ton of sense here.

Los Angeles has yielded the second-fewest points in the NFL. It gave up 16 points to the Seahawks and has registered 31 sacks in nine games. We’ve seen what this type of defensive pressure has done to Brady thus far this season. Given stud guard Ali Marpet won’t play on Monday night, things could get rough for Brady Take the Rams to win outright, pulling off an upset in the process.

NFL Week 11 Thursday Night Football

Arizona Cardinals at Seattle Seahawks

Cardinals-Seahawks Week 11 point spread: Seahawks -3.0 (over/under 57.5)

Injury update: Seahawks RB Chris Carson (foot) unlikely to play

Seahawks quarterback Russell Wilson has turned the ball over eight times over the past four games. It’s not a coincidence that Seattle is 1-3 in those four games. For comparison’s sake, Wilson had turned the ball over a combined eight times in his previous 14 games. The Seahawks were 11-3 in those 14 games. On a short week, it’s hard to imagine Wilson and Co. righting the ship against a flying-high Cardinals squad.

Vincent Frank
Editor here at Sportsnaut. Contributor at Forbes. Previous bylines include Bleacher Report, Yahoo!, SB Nation. Heard on ESPN Radio and NBC Sports Radio. Northern California native living it up in Las Vegas. The Keto lifestyle. Traveler. Reader. TV watcher. Dog daddy. Sam Malone = greatest TV character ever. "Carpe diem. Seize the day, boys. Make your lives extraordinary," John Keating.