Andrew Buller-Russ
While we’re still picking up the pieces from an action-packed slate last weekend, there’s a lot to look forward to on the NFL Week 10 schedule too. This week, there are 14 NFL matchups to preview, featuring 26 teams in action.
Below, we dive into one bold prediction for each game on the Week 10 NFL schedule, from Thursday to Monday.
Related: NFL Power Rankings 2025: Week-by-Week NFL Evaluations of All 32 Teams
Raiders Force 3 Turnovers in Broncos Loss
The Raiders have struggled offensively and defensively. They’ve forced multiple turnovers in just one game, coming against the lowly Titans. This week, they get to face a familiar divisional opponent, though it’s one that’s committed multiple turnovers only twice this season. Denver will be heavy favorites at home, but with Maxx Crosby chasing after Bo Nix, chaos could ensue.
Michael Penix’s 350-Yard Day Helps Falcons Sneak Past Colts
From Bijan Robinson, to Drake London and Kyle Pitts, the 2024 first-round pick has plenty of weapons at his disposal, but we’ve only seen Penix top 300 yards twice in his NFL career. In today’s high-volume passing era, Penix has yet to top 313 yards. But if the Falcons plan on keeping pace with the NFL’s highest-scoring offense, they’ll need their franchise QB to air it out, which could lead to a new career-high 350-yard day.
Vikings Score 40 in Big Win Over Ravens
J.J. McCarthy returned to the Vikings’ lineup after a five-game absence, and he helped lead his team to 27 points for the second time in three starts. Baltimore’s defense has seen undergone changes, but they’re still very vulnerable. If Justin Jefferson, Jordan Addison and Minnesota’s running game can catch fire, we could see Kevin O’Connell’s team score a lot of points on Sunday.
Jaxson Dart’s 3 TD Leads Giants Past Bears
He doesn’t have his top two playmakers after Cam Skattebo and Malik Nabers suffered season-ending injuries, but Jaxson Dart has created a spark in New York. He’s recorded multiple touchdowns in all six of his starts thus far. He’ll get a good chance to build upon those numbers against a Bears defense that’s allowed 72 points in the past two weeks. We might even see Dart’s best game yet.
Jaylen Waddle’s 150-Yard Game Fuels Dolphins Win Over Bills
Now that he’s definitely staying with the Dolphins for the rest of the season, Jaylen Waddle can put all the trade rumors behind him and focus on finishing strong. He can remind everyone why the Dolphins didn’t want to part with their other speedster receiver by putting forth a huge 150-yard game while pushing Miami past Buffalo on Sunday.
Justin Fields’ 100 Rushing Yards Lifts Jets Past Browns
The Jets traded away the best players on defense, but left their playmakers in place on offense. It’s now or never for Justin Fields to show that he’s worthy of receiving regular play time on Sundays. So far, the best way for him to do that is by making plays as a runner rather than a passer, but he might be the best rushing QB in the business.
Baker Mayfield’s 400-Yard Day Helps Bucs Beat Patriots
Baker Mayfield vs Drake Maye sets up what could be a high-scoring affair. Coming into the season, most would expect the Bucs to win this one handily. But the Patriots are one of the NFL’s hottest teams, having won six games in a row. We don’t expect Mayfield to flinch. We could even see him outduel Maye in a game that comes down to the final minute, in which Mayfield leads a game-winning drive that pushes him past 400 yards.
Saints Beat Panthers, Hold Carolina Under 100 Rushing Yards
The Panthers have developed a reputation for having one of the NFL’s best rushing offenses after Rico Dowdle’s breakout year. Meanwhile, the Saints are on a path toward a top-three pick. New Orleans doesn’t have anything but pride to play for, but it always feels good to ruin a divisional opponent’s day, and they can do so by shutting down the rushing attack.
Jakobi Meyers’ 100-Yard Day Helps Jags Top Texans
Meyers just arrived in Jacksonville, but he’ll presumably get plenty of opportunities early on with Travis Hunter set to miss multiple weeks. Lawrence could look Meyers’ way often, and if he proves more consistent than Brian Thomas, don’t be surprised if the Jaguars’ new receiver has a big day.
Marvin Harrison Jr’s 150-Yard Day Lifts Cardinals Over Seahawks
MHJ enjoyed a breakout game in the same week where his Hall of Fame called out the Cardinals’ offense for being hard to watch. Playing with more confidence, we could see Junior build off his performance from last week by putting forth a magnificent 150-yard day.
Christian McCaffrey’s 150 Yards Power 49ers Past Rams
Run CMC has been more effective through the air than he has on the ground in San Francisco this season. Whether it’s through the air or on the ground, McCaffrey is still an electrifying playmaker who’s hard to bring down in the open field. The Rams will be reminded of that on Sunday when he racks up a combined 150+ yards in a big win.
Marcus Mariota’s 3 TD Carries Commanders Over Lions
Jayden Daniels is down for the count, which leaves Marcus Mariota as the next man up. We’ve seen mixed performances from the former No. 1 overall pick this season. The same could be true about the Lions, who are coming off a penalty-riddled loss last Sunday. If Mariota and his playmakers can rattle off some chunk plays, the Lions just might be in for an upset.
Steelers Score 40 in Huge Chargers Win
Despite all the rumors, the Steelers opted to stand pat at the 2025 NFL trade deadline. But that doesn’t mean this offense doesn’t have plenty of potential. Aaron Rodgers and DK Metcalf have been in sync all season long, and if the rushing attack can come together, the Steelers might be able to put up some big numbers on the Chargers, but they’ll have to win the turnover battle too.
Two Packers Record 100 Yards in Green Bay’s Win Over Philadelphia
Tucker Kraft’s season-ending injury is a big blow. But it forces Jordan Love to continue spreading the ball around to the open man. Kraft’s injury could also cause Love to hang in the pocket longer, which could lead to bigger plays downfield. We could even see a pair of Packers record 100-yard games.
Related: 2025 NFL Trade Deadline Winners and Losers: Colts, Cowboys + More
