Table of contents
- Christian McCaffrey, San Francisco 49ers
- Micah Parsons, Green Bay Packers
- Kyler Murray, Arizona Cardinals
- Calais Campbell, Arizona Cardinals
- Matthew Stafford, Los Angeles Rams
- Andrew Thomas, New York Giants
- Malik Nabers, New York Giants
- Will Campbell, New England Patriots
- Jayden Reed, Green Bay Packers
- DeForest Buckner, Indianapolis Colts
- Lavonte David, Tampa Bay Buccaneers
- L’Jarius Sneed, Tennessee Titans
Week 1 of the 2025 NFL season is finally here. There is a ton of hope for fans of every team heading into Sunday’s games. However, key injuries can lead to devastating early-season losses. With that in mind, let’s take a look at the biggest news on the Week 1 NFL injury report.
Christian McCaffrey, San Francisco 49ers
ESPN’s Adam Schefter mentioned on Sunday NFL Countdown that Christian McCaffrey’s goal is to play in Week 1 versus the Seahawks. Heading into Sunday, various reports had him as questionable or even as a game-time decision. Schefter noted his sources suggested there was an 80% chance he would play. Well, the veteran reporter confirmed in a follow-up report that he will be in action on Sunday.
Micah Parsons, Green Bay Packers
Schefter reported this morning that Micah Parsons will make his Packers debut on Sunday versus the Lions. However, expect the new addition to get very limited snaps and be used in third-down packages.
Kyler Murray, Arizona Cardinals
Cardinals beat reporter Darren Urban revealed that Kyler Murray was a surprise late addition to the injury report with an “illness.” However, he is still expected to suit up for Arizona on Sunday.
Tyreek Hill
Calais Campbell, Arizona Cardinals
Pass rush great Calais Campbell did not practice on Thursday, and it is still unclear if he will be on the field in Week 1 versus the Saints. The six-time Pro Bowler is making his return to AZ after playing his first nine seasons in Phoenix.
Matthew Stafford, Los Angeles Rams
Matthew Stafford was expected to be ready for the Rams’ Week 1 game against the Texans. However, with the future Hall of Famer having a chronic back issue, things can change quickly. However, ESPN reports that he will be under center on Sunday afternoon.
Andrew Thomas, New York Giants
Tackle Andrew Thomas will play a key role in a potential Giants bounce-back season in 2025. However, he won’t do that starting in Week 1. ESPN reported on Sunday morning, he will be inactive for their Week 1 clash against the NFC Championship runners-up, the Commanders. He is dealing with a Lisfranc injury that ended his 2024 campaign.
Malik Nabers, New York Giants
Receiver Malik Nabers worried Giants fans when he sat out of practice earlier this week. However, it was confirmed that the rising star pass catcher is expected to be on the field for a big early-season clash against the Commanders on Sunday.
Will Campbell, New England Patriots
Patriots fourth overall pick Will Campbell was questionable heading into Week 1 versus the Raiders. But NFL Network’s Tom Pelissero reports he will make his debut today. With the weather expected to be wet in New England, the big man should be a big help for their ground game.
Jayden Reed, Green Bay Packers
There are big hopes for Jayden Reed heading into the Packers’ season opener. He has progressively improved each season, and 2025 has the potential to be his first 1,000-yard year. However, a foot injury still has him listed as questionable for their game Sunday against Detroit.
DeForest Buckner, Indianapolis Colts
Three-time Pro Bowler DeForest Buckner did not participate in practice on Thursday, and he remains in limbo for the Colts’ game against the Dolphins this weekend. He was limited to just 12 games last season due to a high ankle sprain. This year, a back injury has been nagging him.
Lavonte David, Tampa Bay Buccaneers
The Buccaneers are still hoping Lavonte David will be available for their big Week 1 divisional clash against the Falcons. The team great did not participate in practice on Thursday.
L’Jarius Sneed, Tennessee Titans
Cornerback L’Jarius Sneed was a limited participant in practice this week as he looks to make his way back from a season-ending quad injury in 2024 and a knee procedure during the Summer. He was listed as questionable heading into the Titans matchup with the Broncos today.
