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This time of the year is always fun around the league. NFL Week 12 usually gives us three games on Thanksgiving, but only two will happen after the would-be Thursday finale of Ravens-Steelers was postponed due to Baltimore having multiple COVID-19 cases. Those AFC North rivals will play Sunday to add to an already tremendous amount of marquee matchups — and a “Monday Night Football” game that includes one team in must-win territory.
The biggest game on the slate has to be the defending champion Kansas City Chiefs taking on Tom Brady and the Tampa Bay Buccaneers. Who has the point spread in that game? What are the odds that Tampa holds reigning Super Bowl MVP Patrick Mahomes in check?
Here, we give you NFL Week 12 odds and point spreads with a quick note for each matchup.
Update: Nov. 29, 9:25 AM EST
Related: NFL Week 12 schedule, predictions
NFL Week 12 Sunday games
Los Angeles Chargers at Buffalo Bills
Chargers-Bills Week 12 point spread: Bills -4.5 (over/under 52.0)
Following their blowout Week 11 win over the hapless Jets, these Chargers are 5-2 in games decided by more than one score since the start of last season. They are also 3-16 in one-score games. Meanwhile, Justin Herbert is coming off a record-breaking performance that saw him complete 37-of-49 pass for 366 yards with three touchdowns against New York. Unfortunately, this game is expected to be close. You know what that means for Anthony Lynn and Co.? Another narrow loss. Take Buffalo minus the 5.5.
Tennessee Titans at Indianapolis Colts
Titans-Colts Week 12 point spread: Colts -3.0 (over/under 51.5)
Having lost three of four since a 5-0 start to the season, Tennessee took care of business against the Baltimore Ravens in Week 11. That included a 29-yard game-winning touchdown run from Derrick Henry in overtime. Since the start of last season, these Titans are 12-2 when Henry goes for 100-plus yards on the ground. They are 6-9 when he fails to reach the triple-digit plateau. As for the Colts, they have given up 100 yards or more on the ground just six times since Week 8 of the 2019 season. Strength versus strength here.
Related: If you’re a fan of the Titans, check out #Titans rumors, rankings, and news here.
Carolina Panthers at Minnesota Vikings
Panthers-Vikings Week 12 point spread: Vikings -3.0 (over/under 50.0)
Update: Vikings place WR Adam Thielen on COVID list
Last week’s shutout 20-0 win over the Detroit Lions seemed to be more of am aberration than anything else. Prior to that, the Panthers were giving up an average of 27.2 points per game. In fact, the last time Carolina gave up single-digit points was all the way back in Week 1 of the 2018 season. The moral of this story? Matt Rhule’s defense is still young and unproven. Having tallied 750 total yards and seven touchdowns over the past four games, Dalvin Cook should help Carolina return to reality here. The Vikings at -4.0 seems to be a solid bet.
Cleveland Browns at Jacksonville Jaguars
Browns-Jaguars Week 12 point spread: Browns -7.0 (over/under 48.5)
Update: Jaguars to start Mike Glennon at QB
Cleveland has won seven games since the last time Jacksonville earned a victory. In fact, the Browns are 7-3 for just the second time since 1989. These are not the same old Browns. As evidenced by their win over the Eagles in Week 11, this team can beat you in a multitude of ways. As for the Jaguars, they are being outscored by nearly 10 points per game on the season. Cleveland at -6.5 seems to be a bit too friendly for Jacksonville. Take the Browns and the points here.
New York Giants at Cincinnati Bengals
Giants-Bengals Week 12 point spread: Giants -6.0 (over/under 44.0)
Update: Bengals to start Brandon Allen at QB
The Cincinnati Bengals’ loss of Joe Burrow (ACL) for the remainder of the season puts a major damper on things. Burrow had led an offense that was making major strides under young head coach Zac Taylor. In fact, Cincinnati put up north of 350 total yards in five of his first nine starts. Prior to selecting Burrow, the Bengals had reached that yardage total six times since Week 12 of the 2018 campaign. Almost two full seasons. Take that into account with Brandon Allen getting the call under center.
Related: Top NFL Rookie of the Year candidates
Arizona Cardinals at New England Patriots
Cardinals-Patriots Week 12 point spread: Cardinals -2.0 (over/under 49.0)
Related: NFL Week 12 injury report
We’re not too sure how much it will mean against the 4-6 Patriots come Sunday. But the Cardinals’ defense has taken a major step back under coordinator Vance Joseph over the past month. That span has seen Arizona yield an average of 31.5 points in four games. That has forced Kyler Murray to put the ball up at a high clip, leading to some high-scoring games in the process. It’s in this that I fully expect the Cardinals and Patriots to hit the over easily.
Miami Dolphins at New York Jets
Dolphins-Jets Week 12 point spread: Dolphins -7.0 (over/under 44.5)
Following their 34-28 loss to the Chargers in Week 11, these Jets are 0-10 and officially eliminated from the playoffs. They are being outscored by north of 14 points per game. Heck, New York allowed rookie quarterback Justin Herbert to completed 37-of-49 passes for 366 yards and three touchdowns. However, whenever the Jets are not double-digit underdogs under Adam Gase, it makes sense to take the opposing team and the points. There’s no difference in this one.
Related: NFL hot seat alert
Las Vegas Raiders at Atlanta Falcons
Raiders-Falcons Week 12 point spread: Raiders -3.0 (over/under 53.5)
Update: Falcons WR Julio Jones (hamstring) questionable
Despite their Week 11 loss to the Chiefs, it’s time to give the 6-4 Raiders some credit. Perhaps, put some respect behind their name. Here’s a team that nearly swept Kansas City and has already defeated the New Orleans Saints on the season. Those are the two odds-on Super Bowl favorites. Las Vegas is averaging nearly 29 points per game with Derek Carr accounting for 19 touchdown passes and just three interceptions. I don’t envision Atlanta’s offense being able to contain that in Week 12.
New Orleans Saints at Denver Broncos
Saints-Broncos Week 12 point spread: N/A
NFL news: Broncos to start WR at QB on Sunday
In his first NFL start, Saints quarterback Taysom Hill completed 18-of-23 passes for 233 yards while adding 51 yards on the ground and two rushing scores. It came within the confines of a Saints 24-9 win over the Atlanta Falcons. All said, the Saints racked up 378 total yards of offense en route to winning their seventh consecutive game. New Orleans has now put up at least those 378 yards in eight of 10 games this season. New Orleans was already favored and now the lines are off with Denver playing without a quarterback.
San Francisco 49ers at Los Angeles Rams
49ers-Rams Week 12 point spread: Rams -6.5 (over/under 44.5)
The Rams have now lost three consecutive games to their division rivals. That span has seen Jared Goff throw just four touchdowns while leading Los Angeles to an average of 18 points per game. Things might be different this time around given how many injuries the 49ers are dealing with. However, they do expect to get Richard Sherman back on the field in NFL Week 12. Either way, the Rams at -7.0 seems a bit foolish given Goff’s track record against San Francisco.
Related: NFL mock draft 2023 – CJ Stroud, Bryce Young headline outstanding 2023 NFL Draft class
Kansas City Chiefs at Tampa Bay Buccaneers
Chiefs-Buccaneers Week 12 point spread: Chiefs -3.5 (over/under 56.5)
Postseason included, the Kansas City Chiefs are now 18-1 in their past 19 games. In what can’t be considered shocking news, Patrick Mahomes has accounted for 51 total touchdowns and just six interceptions during that span. The Chiefs are also averaging 31 points per game in those 19 outings, winning by an average of nearly 15 points. Do you expect Tom Brady and Co. to change this trend in Week 12? I highly doubt it.
NFL Week 12 Sunday Night Football
Chicago Bears at Green Bay Packers
Bears-Packers Week 12 point spread: Packers -9.5 (over/under 44.0)
Yuck. Chicago heads into this primetime matchup as losers of four consecutive and averaging under 17 points per game during that span. Don’t expect that to change against an angry Packers team in NFL Week 12. The Bears are also averaging 16 points per outing in their past 10 games against the Packers dating back to 2015. Look for Green Bay to cover, and then some.
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NFL Week 12 Monday Night Football
Seattle Seahawks at Philadelphia Eagles
Seahawks-Eagles Week 12 point spread: Seahawks -6.0 (over/under 49.0)
Fourteen. That’s the number of interceptions Eagles quarterback Carson Wentz has thrown en route to leading his team to a 3-6-1 record this season. Fourteen. The number of interceptions Russell Wilson has thrown in his last 20 games. Thirteen touchdowns and three interceptions. Quarterback splits against the Eagles’ defense. Moral of the story here? Seattle as 5.5-point road favorites seems a bit disrespectful to Wilson and Co.
NFL Week 12 Tuesday Night Football
Baltimore Ravens at Pittsburgh Steelers
Ravens-Steelers Week 12 point spread: Steelers -8 (over/under 41.0)
Update: Ravens RB Mark Ingram, J.K. Dobbins out (COVID-19)
Update: Game moved to Tuesday due to COVID-19 outbreak
Not enough is being made about Pittsburgh’s 10-0 start to the season. Following last week’s 27-3 blowout win over Jacksonville, these Steelers are outscoring their opponents by an average of 12.4 points per game. It’s been domination on both sides of the ball. Set to take on a struggling Ravens squad that has lost three of four, Pittsburgh’s -4.5 spread seems too small, especially with the Ravens’ COVID-19 issues. Go with the Over and don’t think twice about it.
NFL Week 12 Thanksgiving Day game
Houston Texans at Detroit Lions
Texans-Lions Week 12 point spread: Texans -3.0 (over/under 51.5)
Update: Lions WR Kenny Golladay, RB D’Andre Swift unlikely to play
For the first time since Daunte Culpepper was their starting quarterback back in Oct. 2009, the Detroit Lions found themselves shut out last Sunday by the Carolina Panthers in a 20-0 loss. What made this even more miserable for embattled head coach Matt Patricia and Co. is the fact that Carolina had yielded an average of nearly 40 points in its previous two games. It’s hard to imagine Matthew Stafford and the Lions bouncing back on a short week. Take Houston in minor upset fashion.
Washington Football Team at Dallas Cowboys
Washington-Cowboys Week 12 point spread: Cowboys -3.0 (over/under 46.0)
Update: Washington WR Terry McLaurin (ankle) expected to play
After two consecutive narrow losses under the leadership of Alex Smith, Washington finally prevailed last week against Cincinnati by the score of 20-9. Rookie Chase Young led another stingy performance from the Football Team’s defense. Shockingly enough, this has Washington at 3-7 on the season and tied with the Philadelphia Eagles in the win column in the NFC East.
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