Through two games, the San Francisco 49ers have two wins and perhaps the same number of healthy running backs on their roster.
That could create a real issue for them going into their home opener Sunday against the Green Bay Packers in Santa Clara, Calif.
After losing starter Raheem Mostert to a season-ending knee injury during its opener at Detroit, San Francisco then saw JaMycal Hasty go down with a high ankle sprain in last week's 17-11 win at Philadelphia. Hasty was placed on short-term injured reserve, which will require him to miss at least three weeks.
What's more, rookies Elijah Mitchell (shoulder) and Trey Sermon (head) were also dinged up last week. Mitchell is doubtful, while Sermon is in concussion protocol but is in line to play along with Trenton Cannon and Jacques Patrick. Cannon and Patrick have one combined carry.
In addition to all that, last year's leading rusher, Jeff Wilson, isn't expected back until November after suffering a meniscus tear in the offseason. Former Lions running back Kerryon Johnson was elevated from the practice squad to provide depth.
San Francisco also signed eight-year veteran Chris Thompson, who has 1,214 yards in part-time duty with Washington and Jacksonville.
But despite all their injuries at running back, San Francisco is still a 3-point favorite at DraftKings and 3.5 at FanDuel over the Aaron Rodgers-led Packers.
While fans and some media pundits have demanded Shanahan insert Lance into the lineup, Garoppolo is completing 70.9 percent of his passes for 503 yards and no interceptions. He's found a new favorite target in Deebo Samuel, who has 15 catches for 282 yards.
"You don't really make decisions based off your team of just putting a guy in totally just for how that is for him in the future," Shanahan said of playing Garoppolo. "I think that'd be irresponsible to everybody else in the room."
That's not a question across the field.
Rodgers bounced back from a rough outing in a 38-3 season-opening loss to New Orleans with a stat line more characteristic of his career on Monday night, going 22 of 27 for 255 yards and four touchdowns in a 35-17 defeat of Detroit.
Green Bay is being backed by 62 percent of the money and 66 percent of the bets at DraftKings and 68 percent of the bets at FanDuel, where 56 percent of the money was backing San Francisco on Sunday morning.
While Green Bay's defense remains a source of concern, even though it held the Lions scoreless in the second half, Rodgers looked as efficient as ever. He leaned on Davante Adams for his standard 8-catch, 121-yard effort, but also spread the wealth among Robert Tonyan, Aaron Jones and Randall Cobb.
Jones caught three short scoring strikes Monday night and added a fourth touchdown on the ground, lending the team the balance it enjoyed during last season's run to the NFC Championship Game.
Yet Rodgers wasn't completely satisfied, citing a couple of plays on which he failed to connect with Marquez Valdes-Scantling and Allen Lazard. Of course, the time he missed Lazard just happened to be the play he found Tonyan for a go-ahead 22-yard score.
"He is the ultimate competitor and he wants everything to be perfect," Packers coach Matt Lafleur said. "He puts a lot of pressure on himself for him to make it perfect."
Rodgers' task might be tougher with left tackle Elgton Jenkins (ankle) sidelined. Jenkins missed practice on Wednesday after playing all 65 plays Monday night and was ruled out later in the week.
--Field Level Media