Cooper, who is not vaccinated, missed the last two games — both losses — after testing positive for COVID-19 last month.
Earlier reports Tuesday suggested that Cooper was still experiencing symptoms and was in danger of missing a third game.
Cooper, 27, has 44 receptions for 583 yards and five touchdowns in nine games this season. In 50 games since joining Dallas in October 2018, he has 268 catches for 3,611 yards and 24 touchdowns.
The Cowboys (7-4) have been dealing with a COVID-19 outbreak that saw a 13th person enter protocols on Tuesday.
Head coach Mike McCarthy tested positive and will not make the trip to New Orleans, with defensive coordinator Dan Quinn serving as acting head coach against the Saints (5-6).
–Field Level Media