Murray missed practice all week with a left ankle injury sustained during last week’s 24-21 loss to the Green Bay Packers.
Colt McCoy, 35, makes his first start for the Cardinals (7-1) against the NFC West rival 49ers (3-4).
McCoy has played just 14 offensive snaps this season and has not attempted a pass. His most recent NFL start came in Week 14 last season for the New York Giants.
Murray, 24, has passed for 2,276 yards with 17 touchdowns and rushed for 147 yards and three scores in eight starts this season.
Hopkins sat out practices this week with a hamstring injury that limited him to 15 snaps and two catches for 66 yards against the Packers.
Hopkins, 29, has recorded team-leading totals in receptions (35), receiving yards (486) and touchdowns (seven) in eight games this season.
–Field Level Media