San Francisco 49ers running back Elijah Mitchell will miss Thursday night’s game against the host Tennessee Titans due to a knee injury.
It will be the second straight game that Mitchell sits out. He missed Sunday’s 31-13 victory over the Atlanta Falcons due to a concussion and a knee injury. He cleared concussion protocol earlier this week, and the 49ers were hoping the knee would respond.
Mitchell, a rookie, leads San Francisco with 759 rushing yards.
Jeff Wilson Jr. figures to receive most of the rushing work. Wilson rushed for a season-high 110 yards against Atlanta.
The 49ers also ruled out linebacker Dre Greenlaw (groin), safety Talanoa Hufanga (knee) and defensive lineman Maurice Hurst (calf). The club listed linebacker Azeez Al-Shaair (elbow) as questionable.
Safety Jaquiski Tartt (ankle) was a full practice participant on Wednesday and cleared to play.
–Field Level Media