4. San Francisco 49ers @ Washington Redskins, Week 6, 1:00 p.m. ET
This West Coast meets East Coast matchup pairs 49ers head coach Kyle Shanahan up with the team he coached from 2010-2013. It also sees quarterback Kirk Cousins play against the team it was rumored he wished to be traded to.
Shanahan will get to see firsthand if his 49ers made the right decision signing Brian Hoyer rather than acquiring Cousins this offseason in a blockbuster trade.
These two teams have played one another only four times since 2008. San Francisco won the last four contests. But considering the 49ers have won a mere seven games the last two seasons, they are no sure bet to notch this victory, especially three time zones away from the comfort of home.